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Pagano Lab study suggests pathway to keeping endothelial cells young

The results of a recent Pagano Lab study “suggest that targeting TSP1, CD47, or Nox1 could delay or reverse cellular senescence in the endothelium, which could help improve the quality of life for the growing aging population.” (Source)

Meijles DN, Sahoo S, al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJ.  The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1. Sci. Signal. 10, eaaj1784 (2017).

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