See Dr. Pagano’s publications on PubMed

Li Y, Kračun D, Dustin CM, El Massry M, Yuan S, Goossen CJ, DeVallance ER, Sahoo S, St Hilaire C, Gurkar AU, Finkel T, Straub AC, Cifuentes-Pagano E, Pagano PJ. Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2015666118. doi: 10.1073/pnas.2015666118. PMID: 34654740.

Pagano PJ, Ito Y, Tornheim K, Gallop PM, Tauber AI, Cohen RA. An NADPH oxidase superoxide-generating system in the rabbit aorta. Am. J. Physiol. 268:H2274-H2280, 1995.

Pagano PJ, Clark JK, Cifuentes-Pagano ME, Clark SM, Callis GM, and Quinn MT. Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin IIProc. Natl. Acad. Sci. USA  94: 14483-14488, 1997.

Pagano PJ, Chanock SL, Siwik DA, Colucci WS, and Clark JK. Angiotensin II induces p67phox mRNA expression and NADPH oxidase superoxide generation in rabbit aortic adventitial fibroblastsHypertension 32: 331-337, 1998.

Rey FE, Cifuentes ME, Kiarash A, Quinn MT, and Pagano PJA novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O2-  and systolic blood pressure in miceCirc. Res. 89: 408-414, 2001.

Rey FE, Li XC, Carretero OA, Garvin JL, and Pagano PJPerivascular superoxide anion contributes to impairment of endothelium-dependent relaxation. Role of gp91phoxCirculation 106:2497-2502, 2002.

Liu J, Ormsby A, Oja-Tebbe N, and Pagano PJGene transfer of NAD(P)H oxidase inhibitor to the vascular adventitia attenuates medial smooth muscle hypertrophyCirc. Res. 95: 587-594, 2004.

Dourron HM, Jacobson GM, Park JL, Liu J, Reddy DJ, Scheel ML, and Pagano PJPerivascular gene transfer of an NADPH oxidase inhibitor suppresses angioplasty-induced neointimal proliferation of rat carotid arteryAm. J. Physiol. Heart Circ. Physiol. 288: H946-H953, 2005.

Haurani MJ, Cifuentes ME, Shepard AD, and Pagano PJNox4 oxidase overexpression specifically decreases endogenous Nox4 mRNA and inhibits angiotensin II-induced adventitial myofibroblast migrationHypertension. 52:143-9, 2008.

Cascino T, Csanyi G, Al Ghouleh I, Montezano AC, Touyz RM, Haurani MJ, Pagano PJAdventitia-Derived Hydrogen Peroxide Impairs Relaxation of the Rat Carotid Artery via smooth muscle cell p38 Mitogen-Activated Protein Kinase.Antioxid Redox Signal. 2011; 15(6):1507-15, 2011.

Csányi G, Cifuentes-Pagano E, Al Ghouleh I, Ranayhossaini DJ, Egaña L, Lopes LR, Jackson HM, Kelley EE, Pagano PJ.  Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2. Free Radic Biol Med. 51:1116-25, 2011.

Al Ghouleh, I, Khoo, N.K., Knaus, U.G., Griendling, K.K., Touyz, R.M., Thannickal,V.J., Barchowsky, A., Nauseef, W.M., Kelley, E.E., Bauer, P.M., Darley-Usmar, V., Shiva, S., Cifuentes-Pagano, E., Freeman, B.A., Gladwin, M.T., and Pagano, P.J.  Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling. Free Rad Biol Med. 51:1271-1288, 2011.

Frazziano, G., Champion, H.C., and Pagano, P.J.  NADPH oxidase-derived ROS and the regulation of pulmonary vascular tone.  Am. J. Physiol., Heart & Circ., 302:H2166-2177, 2012.

Cifuentes-Pagano, M.E., Csányi, G., and Pagano, P.J.  NADPH oxidase inhibitors: A decade of discovery from Nox2ds to HTS.  Cell Mol. Life Sci., 69:2315-2325, 2012.

Csányi G, Yao M, Rodriguez AI, Al Ghouleh I, Sharifi-Sanjani M, Frazziano G, Huang X, Kelley EE, Isenberg JS, Pagano PJThrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1Arterioscler Thromb Vasc Biol. 32:2966-2973, 2012.

Al Ghouleh I, Frazziano G, Rodriguez AI, Csanyi G, Maniar S, St Croix CM, Kelley EE, Egaña LA, Song GJ, Bisello A, Lee YJ, Pagano PJAquaporin 1, Nox1 and Ask1 mediate oxidant-induced smooth muscle cell hypertrophy.Cardiovasc. Res. 97:134-142, 2013.

Cifuentes-Pagano E, Saha J, Csanyi G, Al Ghouleh I, Sahoo S, Rodriguez A, Wipf P, Pagano PJ, Skoda EM. Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors. Med Chem Comm.  4:1085-90, 2013.

Csányi, G., and Pagano, P.J.  Strategies aimed at Nox4 oxidase inhibition employing peptides from Nox4 B-loop and c-terminus and p22phox N-terminus: an elusive target.  Int. J. Hypertens.  2013:842827-, 2013.

Ghouleh IA, Rodríguez A, Pagano PJ, Csányi G. Proteomic Analysis Identifies an NADPH Oxidase 1 (Nox1)-Mediated Role for Actin-Related Protein 2/3 Complex Subunit 2 (ARPC2) in Promoting Smooth Muscle Cell Migration. Int J Mol Sci. 14(10):20220-35, 2013.

Ranayhossaini  DJ, Rodriguez AI, Sahoo S, Chen BB,  Mallampalli RK, Kelley EE, Csanyi G, Gladwin MT, Romero G, Pagano PJ. Selective Recapitulation of Conserved and Non-Conserved Regions of Putative NOXA1 Activation Domain Confers Isoform-Specific Inhibition of Nox1 Oxidase, Attenuation of Endothelial Cell Nox and Migration. J. Biol. Chem.  288:36437-36450, 2013.

Cifuentes-Pagano E, Saha J, Csányi G, Ghouleh IA, Sahoo S, Rodríguez A, Wipf P, Pagano PJ, Skoda EM. Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors. Med Chem Comm.; 4(7):1085-1092, 2013.

Cifuentes-Pagano E, Meijles DN, Pagano PJThe quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls.. Antioxid Redox Signal. 20(17): 2741-54, 2014.

Frazziano G, Al Ghouleh I, Baust J, Shiva S, Champion HC, Pagano PJNox-derived ROS are acutely activated in pressure overload pulmonary hypertension: indications for a seminal role for mitochondrial Nox4. Am J Physiol Heart Circ Physiol.; 306(2):H197-205, 2014.

Rogers NM, Sharifi-Sanjani M, Csányi G, Pagano PJ, Isenberg JS. Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease. Matrix Biol. 37:92-101, 2014.

Yao M, Rogers NM, Csányi G, Rodriguez AI, Ross MA, St Croix C, Knupp H, Novelli EM, Thomson AW, Pagano PJ, Isenberg JS. Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury. J Am Soc Nephrol. 25(6): 1171-86. Erratum in: J Am Soc Nephrol. 25(8):1884, 2014.

Rodríguez AI, Csányi G, Ranayhossaini DJ, Feck DM, Blose KJ, Assatourian L, Vorp DA, Pagano PJMEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 35(2): 430-8, 2015.

Quesada IM, Lucero A, Amaya C, Meijles DN, Cifuentes ME, Pagano PJ, Castro C. Selective inactivation of NADPH oxidase 2 causes regression of vascularization and the size and stability of atherosclerotic plaques. Atherosclerosis 242(2): 469-75, 2015.

Cifuentes-Pagano ME, Meijles DN, Pagano PJNox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors. Curr Pharm Des. 21(41): 6023-35, 2015.

Meijles DN, Pagano PJNox and Inflammation in the Vascular Adventitia. Hypertension 67(1): 14-9, 2016.

Sahoo S, Meijles DN, Pagano PJNADPH oxidases: key modulators in aging and age-related cardiovascular diseases? Clin Sci (Lond).130(5): 317-35, 2016.

Sahoo S, Meijles DN, Al Ghouleh I, Tandon M, Cifuentes-Pagano E, Sembrat J, Rojas M, Goncharova E, Pagano PJMEF2C-MYOCD and Leiomodin1 Suppression by miRNA-214 Promotes Smooth Muscle Cell Phenotype Switching in Pulmonary Arterial Hypertension. PLoS One. 11(5): e0153780, 2016.

Al Ghouleh I, Meijles DN, Mutchler S, Zhang Q, Sahoo S, Gorelova A, Henrich Amaral J, Rodríguez AI, Mamonova T, Song GJ, Bisello A, Friedman PA, Cifuentes-Pagano ME, Pagano PJBinding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype. Proc Natl Acad Sci U S A. 113(36):E5308-17, 2016.

Meijles DN, Sahoo S, al Ghouleh I, Amaral JH, Bienes-Martinez R, Knupp HE, Attaran S, Sembrat JC, Nouraie SM, Rojas MM, Novelli EM, Gladwin MT, Isenberg JS, Cifuentes-Pagano E, Pagano PJThe matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1. Sci. Signal. 10, eaaj1784 (2017).

Li Y, Cifuentes-Pagano E, DeVallance ER, de Jesus DS, Sahoo S, Meijles DN, Koes D, Camacho CJ, Ross M, St Croix C, Pagano PJ. NADPH oxidase 2 inhibitors CPP11G and CPP11H attenuate endothelial cell inflammation & vessel dysfunction and restore mouse hind-limb flow. Redox Biol. 2019 Apr;22:101143. doi: 10.1016/j.redox.2019.101143. Epub 2019 Feb 15.

de Jesus DS, DeVallance E, Li Y, Falabella M, Guimaraes D, Shiva S, Kaufman BA, Gladwin MT, Pagano PJ. Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration. Redox Biol. 2019 Apr;22:101138. doi: 10.1016/j.redox.2019.101138. Epub 2019 Feb 8.